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Our Lab studies the molecular mechanisms of Progeria (HGPS)

We are interested in exploring the potential connections between normal aging and HGPS

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Hutchinson-Gilford progeria syndrome is a genetic condition characterized by the dramatic, rapid appearance of aging beginning in childhood. Affected children typically look normal at birth and in early infancy, but then grow more slowly than other children and do not gain weight at the expected rate (failure to thrive). Learn More
My laboratory is interested in why and how we age. Specifically, we focus on studying molecular mechanisms of Hutchinson-Gilford progeria syndrome (HGPS), a premature aging disease, and exploring the potential connections betweenHGPS and normal aging. Learn More

Quick Facts

Hutchinson-Gilford progeria syndrome is a genetic condition characterized by the dramatic and rapid appearance of aging; symptoms begin in early childhood.
Progeria syndrome is very rare; only about 130 individuals have been diagnosed since 1886.
Signs and symptoms may include facial changes such as thin, beaked-tipped nose, a small chin, thin lips, protruding ears and prominent eyes; other non-facial features may include joint abnormalities, loss of fat under the skin, hair loss, and aged-looking skin but the child’s intellect and motor skills are usually not altered.
Mutations in the LMNA gene cause Hutchinson-Gilford progeria syndrome due to production of an abnormal lamin A protein.
People inherit the disease; only one copy of the LMNA gene is enough to cause the disease because it is an autosomal dominant gene.