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Kan Cao
Kan CaoPrincipal Investigator

Some of my highlights

My laboratory is interested in why and how we age. Specifically, we focus on studying molecular mechanisms of Hutchinson-Gilford progeria syndrome  (HGPS), a premature aging disease, and exploring the potential connections between HGPS and normal aging. Children with HGPS die at their early teens due to heart attack or stoke. Approximately 90% of the HGPS cases are causedby a de novo mutation at 1824 position of the lamin A gene (C1824T, G608G). This mutation does not affect the coded amino acid, but partially activates a cryptic splice donor site in the exon 11, leading to the production of a mutant lamin A mRNA that contains an internal deletion of 150 base pairs.  This is then translated into a lamin A mutant protein missing 50 amino acids near the C-terminus, termed “progerin”. 
  • 2014  UMCP-UMB Innovative Seed Grant Award
  • 2013  Board Of Visitors (BOV) Assistant Professor Award, CMNS, UMD
  • 2011-2015 New Scholar in Aging Award, Ellison Medical Foundation
  • 2011  RASA Award, UMD 
  • 2010-2014 Pathway to Independence Award, NIH
  • 2009  Peer Review Award at the 7th National Functional Genomics Symposium
  • 2009  NHGRI Scientific Retreat Outstanding Presentation Awards, NIH
  • 2008  NHGRI Scientific Retreat Outstanding Presentation Awards, NIH
  • 2008  Fellows Awards for Research Excellence, NIH  
  • 2007  Fellows Awards for Research Excellence, NIH  
  • 1994   Presidential Award for Academic Excellence, China
  • Zhang H, Xiong ZM, Cao K. Mechanisms controlling the smooth muscle cell death in progeria via down-regulation of poly(ADP-ribose) polymerase 1. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):E2261-70. doi: 10.1073/pnas.1320843111. Epub 2014 May 19. PubMed PMID: 24843141; PubMed Central PMCID: PMC4050581.
  • Wu D, Flannery AR, Cai H, Ko E, Cao K. Nuclear localization signal deletion mutants of lamin A and progerin reveal insights into lamin A processing and emerin targeting. Nucleus. 2014 Jan-Feb;5(1):66-74. doi: 10.4161/nucl.28068. Epub 2014 Feb 4. PubMed PMID: 24637396; PubMed Central PMCID: PMC4028357.
  • Xiong ZM, LaDana C, Wu D, Cao K. An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells. Aging (Albany NY). 2013 Apr;5(4):288-303. PubMed PMID: 23596277; PubMed Central PMCID: PMC3651521.
  • McCord RP, Nazario-Toole A, Zhang H, Chines PS, Zhan Y, Erdos MR, Collins FS, Dekker J, Cao K. Correlated alterations in genome organization, histone methylation, and DNA-lamin A/C interactions in Hutchinson-Gilford progeria syndrome. Genome Res. 2013 Feb;23(2):260-9. doi: 10.1101/gr.138032.112. Epub 2012 Nov 14. PubMed PMID: 23152449; PubMed Central PMCID: PMC3561867.
  • Zhang H, Kieckhaefer JE, Cao K. Mouse models of laminopathies. Aging Cell. 2013 Feb;12(1):2-10. doi: 10.1111/acel.12021. Epub 2012 Nov 26. Review. PubMed PMID: 23095062.
  • Candia J, Maunu R, Driscoll M, Biancotto A, Dagur P, McCoy JP Jr, Sen HN, Wei L, Maritan A, Cao K, Nussenblatt RB, Banavar JR, Losert W. From cellular characteristics to disease diagnosis: uncovering phenotypes with supercells. PLoS Comput Biol. 2013;9(9):e1003215. doi: 10.1371/journal.pcbi.1003215. Epub 2013 Sep 5. PubMed PMID: 24039568; PubMed Central PMCID: PMC3763994.
  • Gordon LB, Cao K, Collins FS. Progeria: translational insights from cell biology. J Cell Biol. 2012 Oct 1;199(1):9-13. doi: 10.1083/jcb.201207072. PubMed PMID: 23027899; PubMed Central PMCID: PMC3461511.
  • Driscoll MK, Albanese JL, Xiong ZM, Mailman M, Losert W, Cao K. Automated image analysis of nuclear shape: what can we learn from a prematurely aged cell? Aging (Albany NY). 2012 Feb;4(2):119-32. PubMed PMID: 22354768; PubMed Central PMCID: PMC3314174.
  • Graziotto JJ, Cao K, Collins FS, Krainc D. Rapamycin activates autophagy in Hutchinson-Gilford progeria syndrome: implications for normal aging and age-dependent neurodegenerative disorders. Autophagy. 2012 Jan;8(1):147-51. doi: 10.4161/auto.8.1.18331. Epub 2012 Jan 1. Review. PubMed PMID: 22170152; PubMed Central PMCID: PMC3336000.
  • Cao K, Blair CD, Faddah DA, Kieckhaefer JE, Olive M, Erdos MR, Nabel EG, Collins FS. Progerin and telomere dysfunction collaborate to trigger cellular senescence in normal human fibroblasts. J Clin Invest. 2011 Jul;121(7):2833-44. doi: 10.1172/JCI43578. Epub 2011 Jun 13. PubMed PMID: 21670498; PubMed Central PMCID: PMC3223819.
  • Cao K, Graziotto JJ, Blair CD, Mazzulli JR, Erdos MR, Krainc D, Collins FS. Rapamycin reverses cellular phenotypes and enhances mutant protein clearance in Hutchinson-Gilford progeria syndrome cells. Sci Transl Med. 2011 Jun 29;3(89):89ra58. doi: 10.1126/scitranslmed.3002346. PubMed PMID: 21715679.
  • Olive M, Harten I, Mitchell R, Beers JK, Djabali K, Cao K, Erdos MR, Blair C, Funke B, Smoot L, Gerhard-Herman M, Machan JT, Kutys R, Virmani R, Collins FS, Wight TN, Nabel EG, Gordon LB. Cardiovascular pathology in Hutchinson-Gilford progeria: correlation with the vascular pathology of aging. Arterioscler Thromb Vasc Biol. 2010 Nov;30(11):2301-9. doi: 10.1161/ATVBAHA.110.209460. Epub 2010 Aug 26. PubMed PMID: 20798379; PubMed Central PMCID: PMC2965471.
  • Capell BC, Olive M, Erdos MR, Cao K, Faddah DA, Tavarez UL, Conneely KN, Qu X, San H, Ganesh SK, Chen X, Avallone H, Kolodgie FD, Virmani R, Nabel EG, Collins FS. A farnesyltransferase inhibitor prevents both the onset and late progression of cardiovascular disease in a progeria mouse model. Proc Natl Acad Sci U S A. 2008 Oct 14;105(41):15902-7. doi: 10.1073/pnas.0807840105. Epub 2008 Oct 6. Erratum in: Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):13143. PubMed PMID: 18838683; PubMed Central PMCID: PMC2562418.
  • Cao K, Capell BC, Erdos MR, Djabali K, Collins FS. A lamin A protein isoform overexpressed in Hutchinson-Gilford progeria syndrome interferes with mitosis in progeria and normal cells. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):4949-54. Epub 2007 Mar 14. PubMed PMID: 17360355; PubMed Central PMCID: PMC1821129.
  • Vong QP, Cao K, Li HY, Iglesias PA, Zheng Y. Chromosome alignment and segregation regulated by ubiquitination of survivin. Science. 2005 Dec 2;310(5753):1499-504. PubMed PMID: 16322459.
  • Cao K, Zheng Y. The Cdc48/p97-Ufd1-Npl4 complex: its potential role in coordinating cellular morphogenesis during the M-G1 transition. Cell Cycle. 2004 Apr;3(4):422-4. Epub 2004 Apr 1. PubMed PMID: 15004522.
  • Li HY, Cao K, Zheng Y. Ran in the spindle checkpoint: a new function for a versatile GTPase. Trends Cell Biol. 2003 Nov;13(11):553-7. PubMed PMID: 14573347.
  • Cao K, Nakajima R, Meyer HH, Zheng Y. The AAA-ATPase Cdc48/p97 regulates spindle disassembly at the end of mitosis. Cell. 2003 Oct 31;115(3):355-67. PubMed PMID: 14636562.
  • Tsai MY, Wiese C, Cao K, Martin O, Donovan P, Ruderman J, Prigent C, Zheng Y. A Ran signalling pathway mediated by the mitotic kinase Aurora A in spindle assembly. Nat Cell Biol. 2003 Mar;5(3):242-8. PubMed PMID: 12577065.
Dr. Cao received her B Sc degree in Biology from the Nanjing University China in 1997 and Ph.D. degree in Biology from the Johns Hopkins University in 2005. She did her postdoctoral fellowship in genomics at the National Institutes of Health between 2005-2010.   She was named the New Scholar in Aging by the Ellison Medical Foundation in 2011, and received the Board of Visitors junior faculty award from the University of Maryland in 2013.

Our Lab Members

Zheng-Mei Xiong, M.D., Ph.D
Zheng-Mei Xiong, M.D., Ph.DResearch Assistant Professor
Mei received her M.Sc. from Guiyang Medical University in China and her Ph.D. from Kansai Medical University in Japan.
I am interested in study of molecular mechanisms underlying Hutchinson Gilford progeria syndrome (HGPS) by utilizing iPS cells as a system. Currently I focus on disclosing mitochondrial defects in progeria disease and developing novel medicines in HGPS therapeutics.
Di Wu, M.S.
Di Wu, M.S.Graduate Student
Di enrolled in BISI-MOCB program in 2011 fall and joined Cao lab in the winter
My current research is to study lamin A processing and regulation in mammalian cells and plants, by first examining the potential effects of cytoplasmic lamin A and progerin using molecular and biochemistry approaches, second investigating the transcriptional regulation of the lamin A gene (LMNA) in mammalian cells using a combination of bioinformatics and molecular biology methods, and third exploring the interaction between LINC and SUN proteins as well as the relationship between Arabidopsis LINC and human lamin A using Arabidopsis as a platform.
Kun Wang, M.S.
Kun Wang, M.S. Graduate Student
Kun Wang received his Master degree in Computer Science from Arkansas State University.
Currently Kun is pursuing his PHD degree in Computational Biology and Bioinformatics program at the University of Maryland.  His research interests include comparative genomics, gene regulation, splicing regulation and quantification.
Julie Choi, M.S.
Julie Choi, M.S.Graduate Student
I studied at Pennsylvania State University, where I majored in Life Sciences with the minors in Microbiology and HDFS, and continued my study at Penn State to pursue a Master’s in Biotechnology.
Brief background about myself:
During my time there at Penn State, I worked in early-stage drug discovery lab at GlaxoSmithKline, and gained industrial research experience besides academic research, which allowed me to have broader and richer perspectives. My experiences with the diverse research topics triggered my interests in the field of orphan diseases and understanding the molecular mechanisms involved in genetic disorders. I found it meaningful and enjoyable especially when approaching the biological questions in rare diseases, such as HGPS.
Projects:
One of the characteristics of Hutchinson-Gilford Progeria Syndrome is indicated by skeletal defects in severe loss of bone along with abnormal bone architecture and skeletal fragility. The patients with HGPS have defects in bone differentiation. My project focuses on examining the HGPS-causing mutations on the beta-catenin pathway on Osteoblast differentiation. I am particularly interested in looking at the potential of activated beta-catenin pathway for recovering HGPS defects in bone-forming osteoblasts.
Linlin Sun, Ph.D
Linlin Sun, Ph.DResearch Associate
I received M.A. from Shandong Agricultural University and Ph.D. in Biochemistry and Molecular Biology from Zhejiang University, China. In December 2014, I joined Cao lab as a postdoctoral fellow.
I am interested in studying human aging, with a focus on the connections between telomere shortening and the accelerated aging disease progeria.

Yani Gete
Yani GeteGraduate Student
Yani earned his BS degree in Biological Science and graduated with honors in the Metropolitan State University of Denver in 2012. Afterwards, he spent the last four years working as a postbac at NIH before joining UMD BISI program. His will focus on the analysis of the cellular stress in the Progeria smooth muscle cells.
Xiaojing Mao, M.S.
Xiaojing Mao, M.S.Graduate Student
Xiaojing earned her Master degree from the University of Southern California, where she studied ribosomal genesis in osteoblast differentiation. Her current project focuses on characterization of the peroxisomes in progeria cells and study the enzymes that carry out the ROS scavenging activities in peroxisomes.
Mason Trappio, B.S.
Mason Trappio, B.S.Lab Technician and Lab Manager
Mason received her undergraduate degree from the University of Maryland and joined the Cao Lab in January 2016

Undergraduate Students

Margaret Ren
Margaret RenUndergraduate Student
Margaret is an undergraduate student at University of Maryland class of 2018 from Columbia, MD. She is double majoring in Cell Biology and Molecular Genetics, and Computer Sciences.

Former Lab Members

  • Haoyue Zhang, Postdoctoral fellow at UPenn
  • Megan Leung, Executive Administrative Assistant
, CBMG, UMD
  • Celeste Witting, Medical student at Northwestern Universit
  • Melissa Bui Truong, Honors and HHMI Student, now an analyst at Stifel Nicolaus
  • Haibei Luo, Ph.D., now a manager at Shanghai Kehua Bio-engineering Co., Ltd., China
  • Zeshan Tariq, Honors and HHMI student, now a postbac fellow at NIH/NIAID
  • Eunae Ko, FDA fellow
  • To-Lam Nguyen, now a medical student at the Univ. of Maryland school of Medicine
  • Florian Bigot
  • Pratima Bharti, Ph.D., now a Scientist at Stem Cell Technologies, GA
  • Jason Albanese, HHMI Student
  • Helen Cai, now a proud dental Student at UPenn Dental School
  • Julia Kieckhaefer, now a graduate student at UPenn
  • Steven Margolis, now a medical student at George Washington Medical school
  • Christina LaDana, now a happy nurse at St Joseph Hospital, Baltimore, MD
  • Michael O’Donovan, Business Development Manager, MP BIOMEDICALS
  • Emily Deboy